Blocking macrophage migration inhibitory factor activity alleviates mouse acute otitis media in vivo.

Jin Zhang,Min Xu,Qingyin Zheng,Yan Zhang,Weijun Ma,Zhaoqiang Zhang

Immunology Letters（2014）

引用 17|浏览9

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摘要

•MIF level was increased in LPS-induced mouse AOM model.•ISO-1 had a potential role in improving the AOM mice hearing levels.•ISO-1 reduced the inflammatory reaction in mouse AOM model.•ISO-1 reduced TLR-4 levels and inhibited NF-κB activation in AOM mice.

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关键词

MIF,AOM,OME,LPS,TLR,TM,ABR,IL,TNF,VEGF,ISO-1

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