A Highly Concise And Convergent Synthesis Of Hcv Polymerase Inhibitor Deleobuvir (Bi 207127): Application Of A One-Pot Borylation-Suzuki Coupling Reaction

ORGANIC LETTERS（2014）

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摘要

A highly concise and convergent synthesis of HCV polymerase inhibitor Deleobuvir (BI 207127, 1) was achieved, featuring efficient Pd-catalyzed one-pot borylation-Suzuki coupling where TFP was identified as the unique ligand effective for these transformations.

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