CDKN2A(p16) and HRAS are frequently mutated in vulvar squamous cell carcinoma.

Marjolijn D Trietsch,Vivian M Spaans,Natalja T ter Haar,Elisabeth M Osse,Alexander A W Peters,Katja N Gaarenstroom,Gert Jan Fleuren

Gynecologic Oncology（2014）

引用 54|浏览24

暂无评分

摘要

•107 vulvar squamous cell carcinomas were screened for somatic mutations and HPV infection.•62% of the tumours carried at least one mutation, with TP53, CDKN2A and HRAS being the most frequent.•Patients with a somatic mutation, and specifically HRAS mutations, have a worse prognosis.

查看译文

关键词

Vulva,Squamous cell carcinoma,Somatic mutation,CDKN2A,HRAS,Survival

AI 理解论文

溯源树

样例

生成溯源树，研究论文发展脉络

Chat Paper

正在生成论文摘要