Pharmacogenetics of the DNA repair pathways in advanced non-small cell lung cancer patients treated with platinum-based chemotherapy.

Ivana Sullivan,Juliana Salazar,Margarita Majem,Cinta Pallarés,Elisabeth Del Río,David Páez,Montserrat Baiget,Agustí Barnadas

Cancer Letters（2014）

引用 81|浏览19

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摘要

•High DNA repair capacity has been related to chemoresistance in NSCLC.•The complexity of DNA repair mechanisms explains the role of multiple genes as putative biomarkers.•Genetic variants in DNA repair genes are associated with platinum efficacy in NSCLC.

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关键词

Non-small cell lung cancer,DNA repair,Single nucleotide polymorphisms,Platinum-based chemotherapy,Radiotherapy

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