Fc receptor-targeting of immunogen as a strategy for enhanced antigen loading, vaccination, and protection using intranasally-administered ex vivo antigen-pulsed dendritic cells

•Efficacy: Effective i.n. vaccination via DCs pulsed ex vivo with FcγR-targeted Ag is demonstrated.•Immune responses: Mucosal, peripheral, humoral, and cellular immune responses are enhanced.•Immune advantages: Traditional adjuvant is not required and inhibition via FcγRIIB is absent.•Clinical advantages: Ability to use a less invasive i.n. route and stimulate CD4 and CD8 responses.•Applications: Vaccines and therapeutics against chronic infectious diseases and cancer.