New tumor suppressor CXXC finger protein 4 inactivates mitogen activated protein kinase signaling.

Haiqi Lu,Wei Jin,Jie Sun,Lifeng Feng,Huiyin Lan,Qi Shen,Yanning Ma,Jiaqiu Li,Yongfang Yue,Hongchuan Jin,Xian Wang

FEBS Letters（2014）

引用 14|浏览21

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摘要

•CXXC4 inhibits MAPK signaling through binding to ERK-1/2.•CXXC4 abrogates the interaction of ERK 1/2 with MEK1/2.•L183 is essential for CXXC4–ERK 1/2 interaction.•EZH2 activates MAPK signaling by inhibiting CXXC4 expression.

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关键词

Enhancer of zeste homologue 2 (EZH2),CXXC finger protein 4 (CXXC4),Mitogen-activated protein kinase (MAPK),Extracellular signal-regulated kinase (ERK),MAP kinase (MEK),Gastric carcinogenesis

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