Pyrrolidinium fullerene induces apoptosis by activation of procaspase-9 via suppression of Akt in primary effusion lymphoma.

Tadashi Watanabe,Shigeo Nakamura,Toshiya Ono,Sadaharu Ui,Syota Yagi,Hiroki Kagawa,Hisami Watanabe,Tomoyuki Ohe,Tadahiko Mashino,Masahiro Fujimuro

Biochemical and Biophysical Research Communications（2014）

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摘要

•Seven fullerenes were evaluated in terms of their cytotoxic effects on B-lymphomas.•Pyrrolidinium fullerene induced apoptosis of KSHV-infected B-lymphoma PEL cells.•The activation of Akt is essential for PEL cell survival.•Pyrrolidinium fullerene activated caspase-9 by inactivating Akt in PEL cells.•Pyrrolidinium fullerene have potential as novel drugs for the treatment of PEL.

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KSHV,HHV-8,PEL

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