Strategies to reduce aspecific adsorption of peptides and proteins in liquid chromatography-mass spectrometry based bioanalyses: an overview.

•Proper solubilization reduces aspecific adsorption of peptides and proteins.•A systematic approach to select the most appropriate solvent for dissolution.•Strategies to reduce sticking of peptides and proteins during sample preparation.•Reduction of adsorption at parts of the LC–MS system (carryover).