Breathing and temperature control disrupted by morphine and stabilized by clonidine in neonatal rats.

Kalpashri Kesavan,Tarrah Ezell,Alexis Bierman,Ana Rita Nunes,Frances J Northington,Clarke G Tankersley,Estelle B Gauda

Respiratory Physiology & Neurobiology（2014）

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摘要

•We compared two sedative-analgesics on breathing and temperature in neonatal rats.•Morphine causes profound respiratory depression and hypothermia.•Clonidine stabilizes body temperature, with only minimal effects on respiration.

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关键词

Sedative-analgesics,Clonidine,Morphine,Respiratory depression,Hypothermia,Metabolism

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