Gatekeeper tyrosine phosphorylation is autoinhibitory for Symbiosis Receptor Kinase.

Anindita Paul,Sandip Samaddar,Avisek Bhattacharya,Anindyajit Banerjee,Abhishek Das,Saikat Chakrabarti,Maitrayee DasGupta

FEBS Letters（2014）

引用 4|浏览4

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摘要

•AhSYMRK autophosphorylates on gatekeeper tyrosine (Y670).•Y670E AhSYMRK is conformationally distinct with severely reduced activity.•AhSYMRK autophosphorylated on gatekeeper tyrosine (pY670) is inactive.•Gatekeeper tyrosine autophosphorylation is autoinhibitory for AhSYMRK.

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关键词

RLK,RTK,IRAK,SYMRK,WT,Trx,CD

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