IL-32θ negatively regulates IL-1β production through its interaction with PKCδ and the inhibition of PU.1 phosphorylation.

FEBS Letters（2014）

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摘要

•IL-32θ attenuates IL-1β production.•IL-32θ interacts with PKCδ and PKCε.•The association with PKCδ and IL-32θ inhibit PKCδ-mediated PU.1 activation.

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关键词

PMA,PKC,LPS,RACE,IRF,TLR

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