Accelerated telomere reduction and hepatocyte senescence in tolerated human liver allografts.

Wulamujiang Aini,Aya Miyagawa-Hayashino,Munetaka Ozeki,Salah Adeeb,Masahiro Hirata,Keiji Tamaki,Shinji Uemoto,Hironori Haga

Transplant Immunology（2014）

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摘要

•Telomeres were shorter than expected for graft age in tolerated liver allografts.•Features of cellular senescence were examined in tolerated grafts.•Tolerated grafts had greater hepatocyte nuclear area than donor livers.•Tolerated grafts were associated with higher p21 expression than donor livers.

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ALT,AST,FFPE,PCR,T-Bil,T/S ratio

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