DNA Ligase IV regulates XRCC4 nuclear localization.

Dailia B Francis,Mikhail Kozlov,Jose Chavez,Jennifer Chu,Shruti Malu,Mary Hanna,Patricia Cortes

DNA Repair（2014）

引用 21|浏览16

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摘要

•DNA Ligase IV controls the nuclear localization of XRCC4.•XRCC4 localizes to the cytoplasm in DNA Ligase IV deficient lymphocytes.•Decreased XRCC4 protein levels were observed in fibroblasts with Ligase IV mutations.

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关键词

DNA Ligase IV,XRCC4,NHEJ,DNA repair,V(D)J recombination

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