Increased levels of serum galectin-3 in patients with primary Sjögren's syndrome: associated with interstitial lung disease.

•Significantly higher levels of serum Gal-3 in pSS patients than in healthy controls.•Higher levels of Gal-3 were associated with positive ANCA in pSS patients with ILD.•The levels of Gal-3 were correlated positively with CRP, FIB, IgG, and IL-17 in pSS.•CRP, FIB, IgG, IL-17 and Gal-3 were higher in pSS with ILD than in pSS without ILD.