Nano-sized titanium dioxide-induced splenic toxicity: a biological pathway explored using microarray technology.

Lei Sheng,Ling Wang,Xuezi Sang,Xiaoyang Zhao,Jie Hong,Shen Cheng,Xiaohong Yu,Dong Liu,Bingqing Xu,Renping Hu,Qingqing Sun,Jie Cheng,Zhe Cheng,Suxin Gui,Fashui Hong

Journal of Hazardous Materials（2014）

引用 54|浏览4

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摘要

•Exposure to TiO2 NPs could be accumulated in the spleen.•Exposure to TiO2 NPs caused spleen lesions in mice.•Exposure to TiO2 NPs resulted in immune dysfunction in mice.•Exposure to TiO2 NPs caused alteration of 1041 genes expression of known function in the spleen.

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关键词

Titanium dioxide nanoparticles,Spleen injury,Splenic dysfunction,Gene-expressed profile

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