Increased long-term potentiation at medial-perforant path-dentate granule cell synapses induced by selective inhibition of histone deacetylase 3 requires Fragile X mental retardation protein.

Aimee V Franklin,James R Rusche,Lori L McMahon

Neurobiology of Learning and Memory（2014）

引用 8|浏览5

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摘要

•Non-selective HDAC inhibition increases LTP at MPP-DGC synapses.•Selective HDAC3 inhibition with RGFP966 increases LTP at MPP-DGC synapses.•HDAC3 inhibition induced increase in LTP requires FMRP.

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关键词

Mental retardation,Plasticity,Excitatory transmission,Hippocampus

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