Perceived stress during pregnancy and the catechol-O-methyltransferase (COMT) rs165599 polymorphism impacts on childhood IQ.

Cognition(2014)

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摘要
•An interaction between the rs165599 polymorphism and antenatal stress on IQ scores was found.•If the G allele is present, antenatal stress can affect IQ at 7 and 11years.•Perceived maternal stress at 3.5 and 7years has an effect on offspring IQ scores.•Higher stress was associated with lower offspring IQ irrespective of rs65599 or rs4680 genotype.
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关键词
Intelligence,Gene-environment,Longitudinal,Maternal stress,Child development
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