Spinal HMGB1 induces TLR4-mediated long-lasting hypersensitivity and glial activation and regulates pain-like behavior in experimental arthritis.

Nilesh M Agalave,Max Larsson,Sally Abdelmoaty,Jie Su,Azar Baharpoor,Peter Lundbäck,Karin Palmblad,Ulf Andersson,Helena Harris,Camilla I Svensson

PAIN®（2014）

引用 149|浏览29

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摘要

Spinal injection of disulfide extracellular high mobility group box-1 protein (HMGB1) induces mechanical hypersensitivity and spinal glial activation, and inhibition of spinal HMGB1 resolves mechanical hypersensitivity induced by collagen antibody-induced arthritis.

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关键词

HMGB1,TLR4,Cytokine,Rheumatoid arthritis,Inflammation,Pain,Hypersensitivity,Spinal cord

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