Genetic association study of QT interval highlights role for calcium signaling pathways in myocardial repolarization

Dan E Arking,Sara L Pulit,Lia Crotti,Pim van der Harst,Patricia B Munroe,Tamara T Koopmann,Nona Sotoodehnia,Elizabeth J Rossin,Michael Morley,Xinchen Wang,Andrew D Johnson,Alicia Lundby,Daníel F Gudbjartsson,Peter A Noseworthy,Mark Eijgelsheim,Yuki Bradford,Kirill V Tarasov,Marcus Dörr,Martina Müller-Nurasyid,Annukka M Lahtinen,Ilja M Nolte,Albert Vernon Smith,Joshua C Bis,Aaron Isaacs,Stephen J Newhouse,Daniel S Evans,Wendy S Post,Daryl Waggott,Leo-Pekka Lyytikäinen,Andrew A Hicks,Lewin Eisele,David Ellinghaus,Caroline Hayward,Pau Navarro,Sheila Ulivi,Toshiko Tanaka,David J Tester,Stéphanie Chatel,Stefan Gustafsson,Meena Kumari,Richard W Morris,Åsa T Naluai,Sandosh Padmanabhan,Alexander Kluttig,Bernhard Strohmer,Andrie G Panayiotou,Maria Torres,Michael Knoflach,Jaroslav A Hubacek,Kamil Slowikowski,Soumya Raychaudhuri,Runjun D Kumar,Tamara B Harris,Lenore J Launer,Alan R Shuldiner,Alvaro Alonso,Joel S Bader,Georg Ehret,Hailiang Huang,W H Linda Kao,James B Strait,Peter W Macfarlane,Morris Brown,Mark J Caulfield,Nilesh J Samani,Florian Kronenberg,Johann Willeit,J Gustav Smith,Karin H Greiser,Henriette Meyer zu Schwabedissen,Karl Werdan,Massimo Carella,Leopoldo Zelante,Susan R Heckbert,Bruce M Psaty,Jerome I Rotter,Ivana Kolcic,Ozren Polašek,Alan F Wright, Maura Griffin,Mark J Daly,David O Arnar,Hilma Hólm,Unnur Thorsteinsdottir,Joshua C Denny,Dan M Roden,Rebecca L Zuvich,Valur Emilsson,Andrew S Plump,Martin G Larson,Christopher J O'Donnell,Xiaoyan Yin,Marco Bobbo,Adamo P D'Adamo,Annamaria Iorio,Gianfranco Sinagra,Angel Carracedo,Steven R Cummings,Michael A Nalls,Antti Jula,Kimmo K Kontula,Annukka Marjamaa,Lasse Oikarinen,Markus Perola,Kimmo Porthan,Raimund Erbel,Per Hoffmann,Karl-Heinz Jöckel,Hagen Kälsch,Markus M Nöthen,Marcel den Hoed,Ruth J F Loos,Dag S Thelle,Christian Gieger,Thomas Meitinger,Siegfried Perz,Annette Peters,Hanna Prucha,Moritz F Sinner,Melanie Waldenberger,Rudolf A de Boer,Lude Franke,Pieter A van der Vleuten,Britt Maria Beckmann,Eimo Martens,Abdennasser Bardai,Nynke Hofman,Arthur A M Wilde,Elijah R Behr,Chrysoula Dalageorgou,John R Giudicessi,Argelia Medeiros-Domingo,Julien Barc,Florence Kyndt,Vincent Probst,Alice Ghidoni,Roberto Insolia,Robert M Hamilton,Stephen W Scherer,Jeffrey Brandimarto,Kenneth Margulies,Christine E Moravec,Fabiola del Greco M,Christian Fuchsberger,Jeffrey R O'Connell,Wai K Lee,Graham C M Watt,Harry Campbell,Sarah H Wild, Nour E El Mokhtari,Norbert Frey,Folkert W Asselbergs,Irene Mateo Leach,Gerjan Navis,Maarten P van den Berg,Dirk J van Veldhuisen,Manolis Kellis,Bouwe P Krijthe,Oscar H Franco,Albert Hofman,Jan A Kors,André G Uitterlinden,Jacqueline C M Witteman,Lyudmyla Kedenko,Claudia Lamina,Ben A Oostra,Gonçalo R Abecasis,Edward G Lakatta,Antonella Mulas,Marco Orrú, David Schlessinger,Manuela Uda,Marcello R P Markus,Uwe Völker,Harold Snieder,Timothy D Spector,Johan Ärnlöv,Lars Lind,Johan Sundström,Ann-Christine Syvänen,Mika Kivimaki,Mika Kähönen,Nina Mononen,Olli T Raitakari,Jorma S Viikari,Vera Adamkova,Stefan Kiechl,Maria Brion,Andrew N Nicolaides,Bernhard Paulweber,Johannes Haerting,Anna F Dominiczak,Fredrik Nyberg,Peter H Whincup,Aroon D Hingorani,Jean-Jacques Schott,Connie R Bezzina,Erik Ingelsson,Luigi Ferrucci,Paolo Gasparini, James F Wilson,Igor Rudan,Andre Franke,Thomas W Mühleisen,Peter P Pramstaller,Terho J Lehtimäki,Andrew D Paterson,Afshin Parsa,Yongmei Liu,Cornelia M van Duijn,David S Siscovick,Vilmundur Gudnason,Yalda Jamshidi,Veikko Salomaa,Stephan B Felix,Serena Sanna,Marylyn D Ritchie,Bruno H Stricker,Kari Stefansson,Laurie A Boyer,Thomas P Cappola,Jesper V Olsen,Kasper Lage,Peter J Schwartz,Stefan Kääb,Aravinda Chakravarti,Michael J Ackerman,Arne Pfeufer,Paul I W de Bakker,Christopher Newton-Cheh

NATURE GENETICS（2014）

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摘要

Christopher Newton-Cheh and colleagues report genome-wide association analyses for QT interval, an electrocardiographic measure reflecting myocardial repolarization, in 100,000 individuals. They identify 35 loci associated with QT interval and highlight a role for calcium regulation in myocardial repolarization.

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关键词

qt interval,calcium,genetic association study

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