Structural insights into the stabilization of MALAT1 noncoding RNA by a bipartite triple helix

Jessica A Brown,David Bulkley,Jimin Wang,Max L Valenstein,Therese A Yario,Thomas A Steitz,Joan A Steitz

NATURE STRUCTURAL & MOLECULAR BIOLOGY（2014）

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摘要

The X-ray crystal structure and biochemical analysis of a triple helix formed between the expression and nuclear retention element (ENE) and the 3′ poly(A) tail of the human long noncoding RNA MALAT-1 reveals the basis of its stability and how it confers resistance to degradation.

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nature structural and molecular biology, science

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