Pulsed electromagnetic field enhances brain-derived neurotrophic factor expression through L-type voltage-gated calcium channel- and Erk-dependent signaling pathways in neonatal rat dorsal root ganglion neurons.

Yuan Li,Xiaodong Yan,Juanfang Liu,Ling Li,Xinghua Hu,Honghui Sun,Jing Tian

Neurochemistry International（2014）

引用 54|浏览5

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摘要

•PEMF (50Hz, 1mT) increased the level of [Ca2+]i in DRGNs.•PEMF (50Hz, 1mT) promoted Bdnf mRNA expression in DRGNs.•The promotion of Bdnf expression was mediated by calcium influx through L-VGCC.•The promotion of Bdnf expression was mediated by Erk-dependent signaling pathways.

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关键词

Electromagnetic field,Calcium,Dorsal root ganglion neurons,Brain-derived neurotrophic factor,Erk inhibitor

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