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Discovery of Pf-5190457, A Potent, Selective, and Orally Bioavailable Ghrelin Receptor Inverse Agonist Clinical Candidate

Samit K. Bhattacharya,Kim Andrews,Ramsay Beveridge,Kimberly O. Cameron,Chiliu Chen,Matthew Dunn,Dilinie Fernando,Hua Gao,David Hepworth,V. Margaret Jackson,Vishal Khot,Jimmy Kong,Rachel E. Kosa,Kimberly Lapham,Paula M. Loria,Allyn T. Londregan,Kim F. McClure,Suvi T. M. Orr,Jigna Patel,Colin Rose,James Saenz,Ingrid A. Stock,Gregory Storer,Maria VanVolkenburg,Derek Vrieze,Guoqiang Wang,Jun Xiao,Yingxin Zhang

ACS medicinal chemistry letters（2014）

Cited 57|Views21
Key words
Ghrelin,ghrelin receptor inverse agonist,ghrelin receptor antagonist,diabetes,PF-5190457
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