Fragment-Based Discovery of 7-Azabenzimidazoles As Potent, Highly Selective, and Orally Active Cdk4/6 Inhibitors
Young Shin Cho,Hayley Angove,Christopher Brain,Christine Hiu-Tung Chen,Hong Cheng,Robert Cheng,Rajiv Chopra,Kristy Chung,Miles Congreve,Claudio Dagostin,Deborah J. Davis, Ruth Felten,John Giraldes,Steven D. Hiscock,Sunkyu Kim,Steven Kovats,Bharat Lagu,Kim Lewry,Alice Loo,Yipin Lu,Michael Luzzio,Wiesia Maniara,Rachel McMenamin,Paul N. Mortenson,Rajdeep Benning,Marc O'Reilly,David C. Rees,Junqing Shen,Troy Smith, Yaping Wang,Glyn Williams,Alison J. -A. Woolford,Wojciech Wrona,Mei Xu, Fan Yang,Steven Howard ACS MEDICINAL CHEMISTRY LETTERS（2012）
关键词
CDK4/6,pRb phosphorylation,mantle cell lymphoma,fragment-based screening,structure-guided optimization
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