Discovery of MK-1220: A Macrocyclic Inhibitor of Hepatitis C Virus NS3/4A Protease with Improved Preclinical Plasma Exposure.
Michael T. Rudd,John A. McCauley,John W. Butcher,Joseph J. Romano,Charles J. McIntyre,Kevin T. Nguyen,Kevin F. Gilbert,Kimberly J. Bush,M. Katharine Holloway,John Swestock,Bang-Lin Wan,Steven S. Carroll,Jillian M. DiMuzio,Donald J. Graham,Steven W. Ludmerer,Mark W. Stahlhut,Christine M. Fandozzi,Nicole Trainor,David B. Olsen,Joseph P. Vacca,Nigel J. Liverton ACS Medicinal Chemistry Letters（2011）
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Hepatitis C,NS3/4A,HCV,macrocycle,ring-closing metathesis
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