An asymmetric PAN3 dimer recruits a single PAN2 exonuclease to mediate mRNA deadenylation and decay

Stefanie Jonas,Mary Christie,Daniel Peter,Dipankar Bhandari,Belinda Loh,Eric Huntzinger,Oliver Weichenrieder,Elisa Izaurralde

NATURE STRUCTURAL & MOLECULAR BIOLOGY（2014）

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摘要

Structural analyses reveal the asymmetric assembly of Neurospora crassa PAN2–PAN3 complex and, along with functional work on the proteins from different species, indicate an essential role for PAN3 in coordinating PAN2-mediated deadenylation with subsequent steps in mRNA decay.

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nature structural and molecular biology, science

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