Hepatitis C NS5A protein: two drug targets within the same protein with different mechanisms of resistance.
Current Opinion in Virology（2014）
摘要
•Resistance mutations to daclatasvir and ledipasvir map to domain I of NS5A.•Resistance mutations to alisporivir map to domain II of NS5A.•Resistance can be delayed with drug combinations acting on both NS5A domains.
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