Chronic overcirculation-induced pulmonary arterial hypertension in aorto-caval shunt.

Alessio Rungatscher,Daniele Linardi,Elisabetta Milani,Grazia Ucci,Elena Nicolato,Flavia Merigo,Beatrice Salvetti,Alessandro Mazzucco,Giovanni Battista Luciani,Giuseppe Faggian

Microvascular Research（2014）

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摘要

Pulmonary arterial hypertension is a common complication of congenital heart defects with left-to-right shunts. Current preclinical models do not reproduce clinical characteristics of shunt-related pulmonary hypertension. Aorto-caval shunt was firstly described as a model of right ventricle volume overload. The pathophysiology and the possible determination of pulmonary arterial hypertension of different periods of shunt exposure are still undefined.

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Ea,Ees,PH,RV,IVC,MRI,VM,EDV,ESV,SV,EF,TAPSE,LV,P–V,PRSW,ESPVR,EDPVR

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