Design and synthesis of phenylisoxazole derivatives as novel human acrosin inhibitors.

Bioorganic & Medicinal Chemistry Letters（2014）

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摘要

A potent human acrosin inhibitor B6 (IC50=1.44μM) was identified by two-round of structure-based drug design.

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关键词

Guanidinophenylpyrazole derivatives,Molecular hybridization,Male contraceptive,Human acrosin inhibitors

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