Identification of a Src kinase SH3 binding site in the C-terminal domain of the human ErbB2 receptor tyrosine kinase.

FEBS Letters（2014）

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摘要

•Polyproline motif included in ErbB2 C-terminal domain.•Fyn SH3 binds ErbB2 PPII motif.•ErbB2 C-terminal domain interacts with a Src kinase.

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关键词

IDP,Proline rich motifs,ErbB2,Src-kinase,SH3 domain and NMR spectroscopy

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