Development and preclinical testing of HNVAC, a cell culture-based H1N1 pandemic influenza vaccine from India.

Nagendra R Hegde,Deepak Kumar,P Panduranga Rao,P Krishna Kumari,Yashpal Kaushik,R Ravikrishnan,Sai D Prasad,Krishna M Ella

Vaccine（2014）

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摘要

•A cell-based influenza vaccine was developed indigenously in India.•Cell substrate and virus seed were extensively characterized.•The vaccine was safe and immunogenic in laboratory animals.•This is the first such platform in the developing world.

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关键词

Influenza,Vaccine,Cell culture,H1N1,Pandemic,Pre-clinical,Safety,Immunogenicity

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