Cell uptake and oral absorption of titanium dioxide nanoparticles.

Toxicology Letters(2014)

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摘要
•TiO2 NPs were readily uptaken by A549 cells in vitro.•Very low translocation of TiO2 NPs through a differentiated Caco-2 monolayer system.•Titanium levels in tissues did not increase after a single oral dose of TiO2 NPs.•Several NPs were observed in the cytoplasm of a cell from a Peyer's Patch by TEM.
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关键词
Oral bioavailability,Caco-2,Titanium dioxide nanoparticles,ICP-MS,TEM
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