Analyses of merlin/NF2 connection to FAK inhibitor responsiveness in serous ovarian cancer.

Nina R Shah,Isabelle Tancioni,Kristy K Ward,Christine Lawson,Xiao Lei Chen,Christine Jean,Florian J Sulzmaier,Sean Uryu,Nichol L G Miller,Denise C Connolly,David D Schlaepfer

Gynecologic Oncology（2014）

引用 45|浏览5

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摘要

•FAK is amplified in ovarian cancer and is linked to decreased patient survival.•Merlin level is low in FAK inhibitor sensitive ovarian carcinoma cells lines.•Merlin may be a predictor to identify patients for treatment with a FAK inhibitor.

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关键词

Ovarian cancer,Focal adhesion kinase,Merlin,Tumor,Biomarker

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