Antimalarial chemotherapy: artemisinin-derived dimer carbonates and thiocarbonates.
Bioorganic & Medicinal Chemistry Letters(2014)
摘要
Several 2-carbon-linked trioxane dimer secondary alcohol carbonates 14 and thiocarbonates 15, combined with mefloquine and administered in a low single oral dose, prolonged the survival times of malaria-infected mice much more effectively than the popular monomeric antimalarial drug artemether plus mefloquine. Three dimer carbonates 14 and one dimer thiocarbonate 15 partially cured malaria-infected mice.
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关键词
SAR,ACT,HPLC,DMAP,Py
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