Repeated intravenous administrations of teneurin-C terminal associated peptide (TCAP)-1 attenuates reinstatement of cocaine seeking by corticotropin-releasing factor (CRF) in rats.

•The results extend our previous work with intracranial administrations of TCAP-1.•Here, repeated IV injections of TCAP-1 attenuated the CRF-induced reinstatement of cocaine seeking in rats.•The TCAP-1 regimen had a differential effect in rats that self-administered cocaine for 6, relative to 3, hours per day.•The results point to a potential therapeutic benefit of TCAP-1 in attenuating cocaine seeking behaviors.