Plasmid carriage of bla NDM-1 in clinical Acinetobacter baumannii isolates from India.

NDM-1 probably emerged in Acinetobacter species prior to its dissemination among Enterobacteriaceae, and NDM-1-like enzymes are increasingly reported in Acinetobacter species. Here, we report on the genetic context of bla(NDM-1) in the earliest known NDM-1-producing organisms, clinical isolates of Acinetobacter from India in 2005. These strains harbor bla(NDM-1) plasmids of different sizes. The gene is associated with the remnants of the Tn125 transposon normally associated with bla(NDM-1) in Acinetobacter spp. The transposon has been disrupted by the IS26 insertion and subsequent movement events.