Heparanase expression and localization in different types of human lung cancer.

Teresa Cristina Fernandes dos Santos,Angélica Maciel Gomes,Marcos Eduardo Machado Paschoal,Mariana Paranhos Stelling,Vivian Mary Barral Dodd Rumjanek,Alyson do Rosário Junior,Paulo Marcos Valiante,Kalil Madi,Heitor Siffert Pereira de Souza,Mauro Sergio Gonçalves Pavão,Morgana Teixeira Lima Castelo-Branco

Biochimica et Biophysica Acta (BBA) - General Subjects（2014）

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摘要

•Heparanase was localized to tumor cells and to cells within the microenvironment.•Heparanase exhibited a differential distribution based on the type of lung tumor.•Heparanase expression correlates with tumor cell differentiation stage in lung cancer.•We show, for the first time, heparanase expression in small cell lung carcinoma.•This study provides knowledge and new insights regarding heparanase in lung cancer.

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关键词

Heparanase,Adenocarcinoma,Squamous cell carcinoma,Large cell carcinoma,Small cell carcinoma

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