Pharmacological chaperones stabilize retromer to limit APP processing

Vincent J Mecozzi,Diego E Berman,Sabrina Simoes, Chris Vetanovetz, Mehraj R Awal,Vivek M Patel,Remy T Schneider,Gregory A Petsko,Dagmar Ringe,Scott A Small

Nature chemical biology（2014）

引用 178|浏览9

暂无评分

摘要

In silico screening identifies a small molecule that stabilizes the interaction between retromer components Vps35 and Vps29. The compound increases traffic of APP away from the endosomal compartment to limit generation of the Aβ peptides involved in Alzheimer's disease pathology.

查看译文

关键词

nature chemical biology, science

AI 理解论文

溯源树

样例

生成溯源树，研究论文发展脉络

Chat Paper

正在生成论文摘要