Polyethyleneimine-coating enhances adenoviral transduction of mesenchymal stem cells.

Xinglei Yao,Na Zhou,Li Wan,Xiaodong Su,Zhao Sun,Hiroyuki Mizuguchi,Yasuo Yoshioka,Shinsaku Nakagawa, Robert Chunhua Zhao,Jian-Qing Gao

Biochemical and Biophysical Research Communications（2014）

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摘要

•High transduction to mesenchymal stem cells using polymer-coated adenovirus vectors.•An adenovirus vector coated with cationic polymer polyethyleneimine was developed.•High adenoviral transduction to mesenchymal stem cells without cytotoxicity.•Efficient gene transfer to mesenchymal stem cells with modified adenovirus vectors.

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关键词

Mesenchymal stem cells,Adenovirus vectors,Polyethyleneimine,Gene transduction

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