Anti-inflammatory and antiviral effects of indirubin derivatives in influenza A (H5N1) virus infected primary human peripheral blood-derived macrophages and alveolar epithelial cells.
Antiviral Research(2014)
摘要
•Indirubin derivatives suppress the pro-inflammatory cytokine IP-10 during influenza A (H5N1) infection.•The indirubin derivative delays the virus replication in the primary cell culture models.•The suppressive effects are associated to the inhibition of cyclin dependent kinases.
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关键词
Influenza,Indirubin,Macrophages,Pneumocytes,IP-10
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