Role of Rare Earth Oxide Nanoparticles (CeO 2 and La 2 O 3 ) in Suppressing the Photobleaching of Fluorescent Organic Dyes

Aqueous solutions with Rhodamine dye, and fluorescently labeled polymer samples of fibrin and collagen were mixed with aqueous dispersions of cerium oxide, lanthanum oxide, iron (II) oxide nanoparticles, and OxyFluor, a commonly used reagent for suppressing photobleaching. From time dependent studies of the fluorescence from these samples, we observed that the dyes in samples containing rare earth oxide nanoparticles exhibited significantly slower rates of fluorescence decay compared to control samples without additives, or containing OxyFluor or iron oxide nanoparticles. We posit that this may be related to the oxygen free radical scavenging properties of rare earth oxides.