Nonhomologous DNA end joining and chromosome aberrations in human embryonic lung fibroblasts treated with environmental pollutants.

Pavel Rossner,Andrea Rossnerova,Olena Beskid,Nana Tabashidze,Helena Libalova,Katerina Uhlirova,Jan Topinka,Radim J Sram

Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis（2014）

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摘要

•We analyzed the effect of air pollutants on NHEJ and chromosome aberrations.•In HEL12469 cells B[a]P and extractable organic matter induced DSBs.•The compounds induced XRCC4 expression and a weak Ku70/80 response.•We found increased frequency of aberrations of chromosomes 1, 2, 4, 5, 7 and 17.•The tested compounds preferentially affected chromosome 7.

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关键词

B[a]P,CA,c-PAH,DSB,DMSO,EOM,FG/100,FISH,γ-H2AX,HEL12469,NEX,NHEJ,PAH,PM,PM2.5,ROS

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