The N-terminal domain of the androgen receptor drives its nuclear localization in castration-resistant prostate cancer cells.

•Region a.a. 294–556 was required for AR androgen-independent nuclear localization.•Region a.a. 1–293 mediates Hsp90 regulation of AR nuclear localization in CRPC cells.•Region a.a. 294–556 was able to enhance DHT-induced import of LBD.•Transactivation of NTD is uncoupled from its modulation of AR nuclear localization.