Myeloperoxidase deficiency attenuates nitrogen mustard-induced skin injuries.

•Myeloperoxidase (MPO) plays an important role in nitrogen mustard (NM)-induced skin injuries.•Study was carried out in C57BL/6J wild type (WT) and B6.129X1-MPOtm1Lus/J (MPO KO) mice.•MPO deletion attenuated inflammatory response and microvesication.•MPO deletion attenuated DNA damage and cell death.•Deletion of MPO might be affecting various signaling pathways and oxidative stress.