Chromene suppresses the activation of inflammatory mediators in lipopolysaccharide-stimulated RAW 264.7 cells

Soo-Jin Heo,Jiyi Jang,Bo-Ram Ye,Min-Sun Kim,Weon-Jong Yoon,Chulhong Oh,Do-Hyung Kang,Ji-Hyeok Lee,Min-Cheol Kang,You-Jin Jeon,Sung-Myung Kang,Daekyung Kim,Kil-Nam Kim

Food and Chemical Toxicology（2014）

引用 29|浏览6

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摘要

•Sargachromanol D from Sargassum siliquastrum inhibited lipopolysaccharide-induced inflammatory mediators.•Sargachromanol D restrained pro-inflammatory cytokines in a dose-dependent manner.•Sargachromanol D frustrated activation of NF-κB and mitogen-activated protein kinases pathways.•Sargachromanol D showed possibility as a therapeutically useful secondary metabolite for inflammation.

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BSA,COX-2,dNTP,DMSO,DMEM,ELISA,ERK,FBS,iNOS,IκB,IL-1β,IL-6,JNK,LPS,MAPKs,NO,NF-κB,PCR,PGE2,SD,TNF-α

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