Application of encoded library technology (ELT) to a protein-protein interaction target: discovery of a potent class of integrin lymphocyte function-associated antigen 1 (LFA-1) antagonists.

Christopher S Kollmann,Xiaopeng Bai,Ching-Hsuan Tsai,Hongfang Yang,Kenneth E Lind,Steven R Skinner,Zhengrong Zhu,David I Israel,John W Cuozzo,Barry A Morgan,Koichi Yuki,Can Xie,Timothy A Springer,Motomu Shimaoka,Ghotas Evindar

Bioorganic & Medicinal Chemistry（2014）

引用 84|浏览15

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摘要

Encoded library technology (ELT) was utilized to identify a class of compounds that disrupt the interaction between lymphocyte function-associated antigen-1 (LFA-1) and its ligand intercellular adhesion molecule-1 (ICAM-1) at submicromolar potency in both ELISA and cell adhesion assays.

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关键词

ELT,LFA-1,ICAM-1,PPI

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