The involvement of FAK and Src in the invasion of cardiomyocytes by Trypanosoma cruzi.

Tatiana G Melo,Amanda R Tucci,Alanderson R Nogueira,Maria de Nazareth S L Meirelles,Mirian C S Pereira

Experimental Parasitology（2014）

引用 11|浏览8

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摘要

•We examined the role of FAK/Src during Trypanosoma cruzi invasion process.•Tyrosine kinase treatments impair T. cruzi entry.•FAK and Src expression and phosphorylation increase during T. cruzi invasion.•knockdown of FAK expression (siRNA or Tet-Fak cells) reduce parasite invasion.

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关键词

FAK,c-Src,Trypanosoma cruzi,Cardiomyocytes,Invasion,Signaling pathway

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