E3-ligase Skp2 regulates β-catenin expression and maintains hematopoietic stem cell homing.

Jing Wang,Fei Han,Szu-Wei Lee,Juan Wu,Chia-Hsin Chan,Xian Zhang,Yuan Gao,Hong-Kai Su,Zi-Zhen Feng,Da-Zhi Xu,Hui-Kuan Lin

Biochemical and Biophysical Research Communications（2014）

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摘要

•Skp2 orchestrates homing ability by maintaining the HSC binding to endosteal niche.•β-Catenin is downregulated in Skp2 difficient HSC.•Skp2 and β-catenin maintain HSC homing ability in a cell cycle independent manner.•Skp2 is a novel and critical regulator for HSC homing.

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关键词

Skp2,HSC,BM,WT,BSA,DAPI,CFSE,LT-HSC,LSK,shRNA

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