Pilot clinical study of boron neutron capture therapy for recurrent hepatic cancer involving the intra-arterial injection of a (10)BSH-containing WOW emulsion.

Hironobu Yanagie,Syushi Higashi,Koji Seguchi,Ichiro Ikushima,Mituteru Fujihara,Yasumasa Nonaka, Kazuyuki Oyama, Syoji Maruyama, Ryo Hatae,Minoru Suzuki,Shin-ichiro Masunaga, Tomoko Kinashi,Yoshinori Sakurai,Hiroki Tanaka,Natsuko Kondo,Masaru Narabayashi,Tetsuya Kajiyama,Akira Maruhashi,Koji Ono,Jun Nakajima,Minoru Ono,Hiroyuki Takahashi,Masazumi Eriguchi

Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine（2014）

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摘要

A 63-year-old man with multiple HCC in his left liver lobe was enrolled as the first patient in a pilot study of boron neutron capture therapy (BNCT) involving the selective intra-arterial infusion of a (10)BSH-containing water-in-oil-in-water emulsion ((10)BSH-WOW). The size of the tumorous region remained stable during the 3 months after the BNCT. No adverse effects of the BNCT were observed. The present results show that (10)BSH-WOW can be used as novel intra-arterial boron carriers during BNCT for HCC.

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