Differential gene expression in the proximal neck of human abdominal aortic aneurysm.

Erik Biros,Corey S Moran,Catherine M Rush,Gabor Gäbel,Charlotte Schreurs,Jan H N Lindeman,Philip J Walker,Maria Nataatmadja,Malcolm West,Lesca M Holdt,Irene Hinterseher,Christian Pilarsky,Jonathan Golledge

Atherosclerosis（2014）

引用 47|浏览5

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摘要

•Increased transcription of the human major histocompatibility complex region within the undilated aorta proximal to an AAA.•Formation of tertiary lymphoid tissue may represent a key immune mechanism taking place at the early stages of AAA.•Investigation of molecules interfering with B cells such as lymphotoxin may identify novel therapeutic targets for AAA.

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关键词

Aortic aneurysm,Abdominal,Tissue array analysis,B-lymphocytes,Inflammation

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