Follistatin interacts with Noggin in the development of the axial skeleton.

Mechanisms of Development(2014)

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摘要
•Loss of Follistatin enhances Noggin mutant axial skeleton defects.•In Noggin mutants, Follistatin aids in maintaining proper somite size.•Follistatin affects somite size following somite formation.•Follistatin limits BMP-mediated lateralization of paraxial mesoderm.•Noggin and Gremlin1 mutation does not reduce somitic Follistatin activation.
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关键词
BMP antagonist,Axial skeleton,Sclerotome,Mouse
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