Follistatin interacts with Noggin in the development of the axial skeleton.
Mechanisms of Development(2014)
摘要
•Loss of Follistatin enhances Noggin mutant axial skeleton defects.•In Noggin mutants, Follistatin aids in maintaining proper somite size.•Follistatin affects somite size following somite formation.•Follistatin limits BMP-mediated lateralization of paraxial mesoderm.•Noggin and Gremlin1 mutation does not reduce somitic Follistatin activation.
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关键词
BMP antagonist,Axial skeleton,Sclerotome,Mouse
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